General Information:

Id: 3,115
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1
article
Reference: Siehnel R et al.(2010) A unique regulator controls the activation threshold of quorum-regulated genes in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A. 107: 7916-7921 [PMID: 20378835]

Interaction Information:

Comment The authors analyzed a unique regulator (named QteE, quorum threshold expression element) that blocks QS gene expression and decreases the half-life of the LasR protein without affecting lasR transcription or translation. Expression of QteE reduces LasR protein stability.
Formal Description
Interaction-ID: 28627

gene/protein

qteE

affects_activity of

process

Acyl-HSL quorum sensing

Comment The authors analyzed a unique regulator (named QteE, quorum threshold expression element) that blocks QS gene expression and decreases the half-life of the LasR protein without affecting lasR transcription or translation. Expression of QteE reduces LasR protein stability.
Formal Description
Interaction-ID: 28628

gene/protein

qteE

decreases_quantity of

gene/protein

lasR

Drugbank entries Show/Hide entries for lasR
Comment QteE independently blocks RhlR protein accumulation and signaling by the rhl system.
Formal Description
Interaction-ID: 28629

gene/protein

qteE

decreases_quantity of

gene/protein

rhlR

Comment QteE is required to produce the quorum expression threshold characteristic of some QS-regulated genes including rsaL, lasB, pa1656, and lasI.
Formal Description
Interaction-ID: 28630

gene/protein

qteE

affects_expression of

gene/protein

rsaL

Comment QteE is required to produce the quorum expression threshold characteristic of some QS-regulated genes including rsaL, lasB, pa1656, and lasI.
Formal Description
Interaction-ID: 28631

gene/protein

qteE

affects_expression of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment QteE is required to produce the quorum expression threshold characteristic of some QS-regulated genes including rsaL, lasB, pa1656, and lasI.
Formal Description
Interaction-ID: 28632

gene/protein

qteE

affects_expression of

gene/protein

PA1656

Comment QteE is required to produce the quorum expression threshold characteristic of some QS-regulated genes including rsaL, lasB, pa1656, and lasI.
Formal Description
Interaction-ID: 28633

gene/protein

qteE

affects_expression of

gene/protein

lasI

Comment Induced expression of qteE also reduced rhamnolipid, protease, elastase, and pyocyanin levels to those seen in a P. aeruginosa mutant lacking QS.
Formal Description
Interaction-ID: 28634

gene/protein

qteE

affects_quantity of

cellular component

rhamnolipid

Comment Induced expression of qteE also reduced rhamnolipid, protease, elastase, and pyocyanin levels to those seen in a P. aeruginosa mutant lacking QS.
Formal Description
Interaction-ID: 28635

gene/protein

qteE

affects_quantity of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment Induced expression of qteE also reduced rhamnolipid, protease, elastase, and pyocyanin levels to those seen in a P. aeruginosa mutant lacking QS.
Formal Description
Interaction-ID: 28636

gene/protein

qteE

affects_quantity of

drug/chemical compound

Pyocyanine