General Information:

Id: 3,113 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1
article
Reference: Soscia C et al.(2007) Cross talk between type III secretion and flagellar assembly systems in Pseudomonas aeruginosa. J. Bacteriol. 189: 3124-3132 [PMID: 17307856]

Interaction Information:

Comment The overproduction of ExsA decreased the level of expression of the fliA-lacZ fusion by 2.2-fold, suggesting that ExsA, under T3SS-inducing conditions, has a negative effect on the expression of flagellar genes when it is overproduced. It was proposed that a cross talk exists between flagellum assembly and T3SS function.
Formal Description
Interaction-ID: 28603

gene/protein

exsA

increases_activity of

process

T3SS

Comment The overproduction of ExsA decreased the level of expression of the fliA-lacZ fusion by 2.2-fold, suggesting that ExsA, under T3SS-inducing conditions, has a negative effect on the expression of flagellar genes when it is overproduced. It was proposed that a cross talk exists between flagellum assembly and T3SS function.
Formal Description
Interaction-ID: 28604

gene/protein

exsA

increases_expression of

complex/PPI

T3SS complex

Comment The overproduction of ExsA decreased the level of expression of the fliA-lacZ fusion by 2.2-fold, suggesting that ExsA, under T3SS-inducing conditions, has a negative effect on the expression of flagellar genes when it is overproduced. It was proposed that a cross talk exists between flagellum assembly and T3SS function.
Formal Description
Interaction-ID: 28605

gene/protein

exsA

decreases_expression of

gene/protein

fliA

if ExsA is overexpressed