General Information:

Id: 3,113
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1
article
Reference: Soscia C et al.(2007) Cross talk between type III secretion and flagellar assembly systems in Pseudomonas aeruginosa. J. Bacteriol. 189: 3124-3132 [PMID: 17307856]

Interaction Information:

Comment The overproduction of ExsA decreased the level of expression of the fliA-lacZ fusion by 2.2-fold, suggesting that ExsA, under T3SS-inducing conditions, has a negative effect on the expression of flagellar genes when it is overproduced. It was proposed that a cross talk exists between flagellum assembly and T3SS function.
Formal Description
Interaction-ID: 28603

gene/protein

exsA

increases_activity of

process

T3SS

Comment The overproduction of ExsA decreased the level of expression of the fliA-lacZ fusion by 2.2-fold, suggesting that ExsA, under T3SS-inducing conditions, has a negative effect on the expression of flagellar genes when it is overproduced. It was proposed that a cross talk exists between flagellum assembly and T3SS function.
Formal Description
Interaction-ID: 28604

gene/protein

exsA

increases_expression of

complex/PPI

T3SS complex

Comment The overproduction of ExsA decreased the level of expression of the fliA-lacZ fusion by 2.2-fold, suggesting that ExsA, under T3SS-inducing conditions, has a negative effect on the expression of flagellar genes when it is overproduced. It was proposed that a cross talk exists between flagellum assembly and T3SS function.
Formal Description
Interaction-ID: 28605

gene/protein

exsA

decreases_expression of

gene/protein

fliA

if ExsA is overexpressed
Comment In P. aeruginosa strain PAO1, the presence of a functional flagellar system repressed the T3SS regulon. Such repression involves genes encoding structural components (secretion, translocation, and regulatory components) as well as effector genes.
Formal Description
Interaction-ID: 28608

cellular component

flagellum

decreases_activity of

process

T3SS

Comment In P. aeruginosa strain PAO1, the presence of a functional flagellar system repressed the T3SS regulon. Such repression involves genes encoding structural components (secretion, translocation, and regulatory components) as well as effector genes.
Formal Description
Interaction-ID: 28609

cellular component

flagellum

decreases_expression of

complex/PPI

T3SS complex

Comment The fliC mutation (nonflagellated strain) specifically influences ExoS and the T3SS. Under T3SS-inducing conditions (lacking Ca2+), ExoS secretion was significantly increased in the PAO1 delta-fliC mutant compared to that in the parental strain. The levels of elastase secretion via T2SS were similar in the PAO1 parental strain and its isogenic PAO1 delta-fliC mutant derivative.
Formal Description
Interaction-ID: 28610

cellular component

flagellum

decreases transport of

gene/protein

exoS

Comment The fliC mutation (nonflagellated strain) specifically influences ExoS and the T3SS. Under T3SS-inducing conditions (lacking Ca2+), ExoS secretion was significantly increased in the PAO1 delta-fliC mutant compared to that in the parental strain. The levels of elastase (lasB) secretion via T2SS were similar in the PAO1 parental strain and its isogenic PAO1 delta-fliC mutant derivative.
Formal Description
Interaction-ID: 28612

cellular component

flagellum

NOT affects transport of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment In P. aeruginosa, the mobility of the gacA mutants was reduced in comparison to that of the parental strain, showing that GacA activated the flagellar regulon.
Formal Description
Interaction-ID: 28613

gene/protein

gacA

increases_quantity of

cellular component

flagellum

Comment The level of ExoS secretion was clearly enhanced in the gacA mutant strain under T3SS induction. This observation reveals that GacA negatively affects the function of T3SS, which is then controlled in a manner opposite to that for the flagellum.
Formal Description
Interaction-ID: 28619

gene/protein

gacA

decreases transport of

gene/protein

exoS

Comment The level of ExoS secretion was clearly enhanced in the gacA mutant strain under T3SS induction. This observation reveals that GacA negatively affects the function of T3SS, which is then controlled in a manner opposite to that for the flagellum.
Formal Description
Interaction-ID: 28620

gene/protein

gacA

decreases_activity of

process

T3SS