General Information:

Id: 3,101
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain P14
article
Reference: Lesic B et al.(2007) Inhibitors of pathogen intercellular signals as selective anti-infective compounds. PLoS Pathog. 3: 1229-1239 [PMID: 17941706]

Interaction Information:

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) inhibit the biosynthesis HHQ, PQS and HQNO, which are representative congeners of the three principal HAQ series, in PA14 cultures. The halogenated AA analogs did not significantly perturb PA14 growth kinetics.
Formal Description
Interaction-ID: 28452

drug/chemical compound

6FABA

decreases_quantity of

drug/chemical compound

2-Heptyl-4-quinolone, HHQ

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) inhibit the biosynthesis HHQ, PQS and HQNO, which are representative congeners of the three principal HAQ series, in PA14 cultures. The halogenated AA analogs did not significantly perturb PA14 growth kinetics.
Formal Description
Interaction-ID: 28453

drug/chemical compound

6FABA

decreases_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) inhibit the biosynthesis HHQ, PQS and HQNO, which are representative congeners of the three principal HAQ series, in PA14 cultures. The halogenated AA analogs did not significantly perturb PA14 growth kinetics.
Formal Description
Interaction-ID: 28454

drug/chemical compound

6FABA

decreases_quantity of

drug/chemical compound

2-Heptyl-4-hydroxyquinoline N-oxide, HQNO

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) inhibit the biosynthesis HHQ, PQS and HQNO, which are representative congeners of the three principal HAQ series, in PA14 cultures. The halogenated AA analogs did not significantly perturb PA14 growth kinetics.
Formal Description
Interaction-ID: 28455

drug/chemical compound

6CABA

decreases_quantity of

drug/chemical compound

2-Heptyl-4-quinolone, HHQ

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) inhibit the biosynthesis HHQ, PQS and HQNO, which are representative congeners of the three principal HAQ series, in PA14 cultures. The halogenated AA analogs did not significantly perturb PA14 growth kinetics.
Formal Description
Interaction-ID: 28456

drug/chemical compound

6CABA

decreases_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) inhibit the biosynthesis HHQ, PQS and HQNO, which are representative congeners of the three principal HAQ series, in PA14 cultures. The halogenated AA analogs did not significantly perturb PA14 growth kinetics.
Formal Description
Interaction-ID: 28457

drug/chemical compound

6CABA

decreases_quantity of

drug/chemical compound

2-Heptyl-4-hydroxyquinoline N-oxide, HQNO

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) inhibit the biosynthesis HHQ, PQS and HQNO, which are representative congeners of the three principal HAQ series, in PA14 cultures. The halogenated AA analogs did not significantly perturb PA14 growth kinetics.
Formal Description
Interaction-ID: 28458

drug/chemical compound

4CABA

decreases_quantity of

drug/chemical compound

2-Heptyl-4-quinolone, HHQ

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) inhibit the biosynthesis HHQ, PQS and HQNO, which are representative congeners of the three principal HAQ series, in PA14 cultures. The halogenated AA analogs did not significantly perturb PA14 growth kinetics.
Formal Description
Interaction-ID: 28459

drug/chemical compound

4CABA

decreases_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) inhibit the biosynthesis HHQ, PQS and HQNO, which are representative congeners of the three principal HAQ series, in PA14 cultures. The halogenated AA analogs did not significantly perturb PA14 growth kinetics.
Formal Description
Interaction-ID: 28460

drug/chemical compound

4CABA

decreases_quantity of

drug/chemical compound

2-Heptyl-4-hydroxyquinoline N-oxide, HQNO

Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) limit P. aeruginosa virulence in a thermal injury mice model.
Formal Description
Interaction-ID: 28461

drug/chemical compound

6FABA

decreases_activity of

process

P. aeruginosa infection

in a thermal injury mice model
Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) limit P. aeruginosa virulence in a thermal injury mice model.
Formal Description
Interaction-ID: 28462

drug/chemical compound

6CABA

decreases_activity of

process

P. aeruginosa infection

in a thermal injury mice model
Comment The halogenated AA (anthranilic acid) analogs 6FABA (2-amino-6-fluorobenzoic acid), 6CABA (2-amino-6-chlorobenzoic acid) and 4CABA (2-amino-4-chlorobenzoic acid) limit P. aeruginosa virulence in a thermal injury mice model.
Formal Description
Interaction-ID: 28463

drug/chemical compound

4CABA

decreases_activity of

process

P. aeruginosa infection

in a thermal injury mice model