General Information:

Id: 3,089 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PA14
article
Reference: Lesic B et al.(2009) Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis. Microbiology (Reading 155: 2845-2855 [PMID: 19497948]

Interaction Information:

Comment The mvfR inhibitors 4CABA (2-amino-4-chlorobenzoic acid) and 6CABA (2-amino-6-chlorobenzoic acid) repressed transcription of about half of the HSI-II-associated genes and almost all of the HSI-III-associated genes. The downregulation of hcp2 and hcp3 transcription by 4CABA and 6CABA was further confirmed by qRT-PCR.
Formal Description
Interaction-ID: 28368

drug/chemical compound

4CABA

decreases_activity of

gene/protein

mvfR