General Information:

Id: 3,089 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PA14
article
Reference: Lesic B et al.(2009) Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis. Microbiology (Reading 155: 2845-2855 [PMID: 19497948]

Interaction Information:

Comment MvfR and LasR positively regulate hcp2 and hcp3 and negatively regulate hcp1. The results demonstrate that the expression of all three PA14 T6S loci was affected by QS, although the regulation may not be due to direct binding of LasR or MvfR. Both the LasR and MvfR systems negatively affect HSI-I transcription and positively affect transcription of HSI-II and HSI-III.
Formal Description
Interaction-ID: 28357

gene/protein

mvfR

increases_expression of

complex/PPI

T6SS-HSI-3 complex

shown in a microarray and qRT-PCR approach