General Information:

Id: 3,011 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000182 HT-29 cell, cocultured with P. aeruginosa strain PA103-delta-UT expressing plasmid-encoded ExoS-HA (Pa-ExoS-HA)
Reference: Bridge DR et al.(2010) Role of host cell polarity and leading edge properties in Pseudomonas type III secretion. Microbiology (Reading 156: 356-373 [PMID: 19910414]

Interaction Information:

Comment PFO (Perfringolysin O) affects membrane properties differently from M-beta-CD (methyl-beta-cyclodextrin), causing oligomerization of membrane cholesterol in conjunction with pore formation. PFO allowed translocon insertion but not effector translocation.
Formal Description
Interaction-ID: 27489

drug/chemical compound

Perfringolysin O

decreases transport of