General Information:

Id: 3,011 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000182 HT-29 cell, cocultured with P. aeruginosa strain PA103-delta-UT expressing plasmid-encoded ExoS-HA (Pa-ExoS-HA)
article
Reference: Bridge DR et al.(2010) Role of host cell polarity and leading edge properties in Pseudomonas type III secretion. Microbiology (Reading 156: 356-373 [PMID: 19910414]

Interaction Information:

Comment M-beta-CD (methyl-beta-cyclodextrin) depletes membrane cholesterol, and in dose-response studies, treatment of HT-29 epithelial cells with M-beta-CD, prior to co-culture with Pa-ExoS-HA, caused a decrease in T3S effector ExoS translocation.
Formal Description
Interaction-ID: 27476

drug/chemical compound

Methyl-beta-cyclodextrin

decreases transport of

gene/protein

exoS