General Information:

Id: 3,006 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
reporter system based on Bla/CCF2 enzyme/substrate combination
article
Reference: Verove J et al.(2012) Injection of Pseudomonas aeruginosa Exo Toxins into Host Cells Can Be Modulated by Host Factors at the Level of Translocon Assembly and/or Activity. PLoS ONE 7 [PMID: 22299042]

Interaction Information:

Comment ExoS-Bla injection into VD3-dHL-60 was abolished by genistein, a large spectrum tyrosine kinase inhibitor, by PP2, an inhibitor of the Src-kinase(s), and by PF-5732208, an inhibitor of focal adhesion tyrosine kinases, FAK and Pyk2.
Formal Description
Interaction-ID: 27427

drug/chemical compound

Genistein

decreases transport of

gene/protein

exoS

into VD3-dHL-60 cells
Drugbank entries Show/Hide entries for Genistein