General Information:

Id: 3,006 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
reporter system based on Bla/CCF2 enzyme/substrate combination
article
Reference: Verove J et al.(2012) Injection of Pseudomonas aeruginosa Exo Toxins into Host Cells Can Be Modulated by Host Factors at the Level of Translocon Assembly and/or Activity. PLoS ONE 7 [PMID: 22299042]

Interaction Information:

Comment Two specific PI3-kinase inhibitors, wortmannin and LY-294002 inhibited the translocation of ExoS-Bla, suggesting the involvement of PI3K signalling pathway in the translocon activity.
Formal Description
Interaction-ID: 27425

drug/chemical compound

LY294002

decreases transport of

gene/protein

exoS

into VD3-dHL-60 cells