General Information:

Id: 3,006 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
reporter system based on Bla/CCF2 enzyme/substrate combination
article
Reference: Verove J et al.(2012) Injection of Pseudomonas aeruginosa Exo Toxins into Host Cells Can Be Modulated by Host Factors at the Level of Translocon Assembly and/or Activity. PLoS ONE 7 [PMID: 22299042]

Interaction Information:

Comment The actin network appears to play a major role in the translocation process in the VD3-differentiated-HL-60 model as evidenced by the action of cytochalasin D and latrunculin B, two actin-depolymerizing agents which were found to markedly inhibit the injection of ExoS-Bla.
Formal Description
Interaction-ID: 27379

drug/chemical compound

Cytochalasin D

decreases transport of

gene/protein

exoS

into VD3-dHL-60 cells