General Information:

Id: 3,006 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
reporter system based on Bla/CCF2 enzyme/substrate combination
article
Reference: Verove J et al.(2012) Injection of Pseudomonas aeruginosa Exo Toxins into Host Cells Can Be Modulated by Host Factors at the Level of Translocon Assembly and/or Activity. PLoS ONE 7 [PMID: 22299042]

Interaction Information:

Comment Cholesterol-rich membrane microdomains have been implicated in invasion of P. aeruginosa. Depletion of cholesterol from lipid rafts by methyl-beta-cyclodextrin abolished the translocation of the reporter ExoS-Bla in a dose-dependent manner. Co-localisation of PopB with the lipid raft marker flotillin is further supporting the role of lipid rafts in the translocation process.
Formal Description
Interaction-ID: 27377

drug/chemical compound

Methyl-beta-cyclodextrin

decreases transport of

gene/protein

exoS

by cholesterol removal of cultured cells