General Information:

Id: 2,953
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa
article
Reference: Douzi B et al.(2011) Deciphering the Xcp Pseudomonas aeruginosa type II secretion machinery through multiple interactions with substrates. J. Biol. Chem. 286 [PMID: 21949187]

Interaction Information:

Comment The authors systematically assayed in vitro interactions between the periplasmic soluble domains of XcpP(C) and various periplasmic domains of secreton components. There was an interaction between the soluble domains of XcpP(C) and XcpQ(D).
Formal Description
Interaction-ID: 26932

gene/protein

xcpP

interacts (colocalizes) with

gene/protein

xcpQ

experiments performed with the periplasmic soluble domains
Comment The purified Xcp substrates LasB and LipA interact with XcpP(C), as shown by SPR (surface plasmon resonance) .
Formal Description
Interaction-ID: 26937

gene/protein

xcpP

interacts (colocalizes) with

gene/protein

lasB

experiments performed with the periplasmic soluble domains
Drugbank entries Show/Hide entries for lasB
Comment The purified Xcp substrates LasB and LipA interact with XcpP(C), as shown by SPR (surface plasmon resonance) .
Formal Description
Interaction-ID: 26938

gene/protein

xcpP

interacts (colocalizes) with

gene/protein

lipA

experiments performed with the periplasmic soluble domains
Drugbank entries Show/Hide entries for lipA
Comment LasB binds the N0N1 secretin XcpQ subdomains. There are two different interaction sites on XcpQ(D): one for XcpP(C) and another for LasB.
Formal Description
Interaction-ID: 26943

gene/protein

xcpQ

interacts (colocalizes) with

gene/protein

lasB

experiments performed with the periplasmic soluble domains
Drugbank entries Show/Hide entries for lasB
Comment LasB interacts with the pseudopilus tip. Individual interactions between pseudopilins and LasB indicated that three of the four minor pseudopilin soluble domains, XcpU(H), XcpV(I), and XcpX(K), interacted with the substrate LasB, whereas XcpW(J) did not show any significant binding.
Formal Description
Interaction-ID: 26946

gene/protein

lasB

interacts (colocalizes) with

gene/protein

xcpU

experiments performed with the periplasmic soluble domains
Drugbank entries Show/Hide entries for lasB
Comment LasB interacts with the pseudopilus tip. Individual interactions between pseudopilins and LasB indicated that three of the four minor pseudopilin soluble domains, XcpU(H), XcpV(I), and XcpX(K), interacted with the substrate LasB, whereas XcpW(J) did not show any significant binding.
Formal Description
Interaction-ID: 26948

gene/protein

lasB

interacts (colocalizes) with

gene/protein

xcpV

experiments performed with the periplasmic soluble domains
Drugbank entries Show/Hide entries for lasB
Comment LasB interacts with the pseudopilus tip. Individual interactions between pseudopilins and LasB indicated that three of the four minor pseudopilin soluble domains, XcpU(H), XcpV(I), and XcpX(K), interacted with the substrate LasB, whereas XcpW(J) did not show any significant binding.
Formal Description
Interaction-ID: 26949

gene/protein

lasB

interacts (colocalizes) with

gene/protein

xcpX

experiments performed with the periplasmic soluble domains
Drugbank entries Show/Hide entries for lasB