General Information:

Id: 2,932
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PA14
article
Reference: Kesarwani M et al.(2011) A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes PLoS Pathog. 7 [PMID: 21829370]

Interaction Information:

Comment The synthesis of 2-amino acetophenone (2-AA), responsible for the grape-like odor of P. aeruginosa cultures and of wound infections, is controlled by the multiple virulence factor regulator (MvfR) important for virulence in acute infections.
Formal Description
Interaction-ID: 26798

gene/protein

mvfR

affects_quantity of

drug/chemical compound

2-Amino acetophenone, 2-AA

Comment 2-amino acetophenone (2-AA) reduces the production of MvfR-regulated acute virulence factors, and attenuates acute virulence by negatively fine-tuning the MvfR regulon activity.
Formal Description
Interaction-ID: 26799

drug/chemical compound

2-Amino acetophenone, 2-AA

decreases_activity of

process

P. aeruginosa infection, acute

Comment 2-amino acetophenone (2-AA) adapts P. aeruginosa for chronic infections by promoting mutations in a key acute virulence gene (lasR) and by prolonging bacterial survival.
Formal Description
Interaction-ID: 26800

drug/chemical compound

2-Amino acetophenone, 2-AA

increases_activity of

process

P. aeruginosa infection, chronic

Comment 2-amino acetophenone (2-AA), but not 2,4-dihydroxyquinoline (DHQ), greatly reduced pqsA expression.
Formal Description
Interaction-ID: 26802

drug/chemical compound

2-Amino acetophenone, 2-AA

decreases_expression of

gene/protein

pqsA

Comment 2-amino acetophenone (2-AA), but not 2,4-dihydroxyquinoline (DHQ), greatly reduced pqsA expression.
Formal Description
Interaction-ID: 26803

drug/chemical compound

2,4-Dihydroxyquinoline, DHQ

NOT decreases_expression of

gene/protein

pqsA

Comment 2-amino acetophenone (2-AA) inhibition of MvfR is likely mediated via negative feedback regulation given that MvfR controls 2-AA synthesis.
Formal Description
Interaction-ID: 26804

drug/chemical compound

2-Amino acetophenone, 2-AA

decreases_activity of

gene/protein

mvfR

Comment 2-heptyl-4-quinolone (HHQ) production was also inhibited by 2-amino acetophenone (2-AA) in a dose-dependent manner.
Formal Description
Interaction-ID: 26805

drug/chemical compound

2-Amino acetophenone, 2-AA

decreases_quantity of

drug/chemical compound

2-Heptyl-4-quinolone, HHQ

Comment 2-amino acetophenone (2-AA) decreased production of pyocyanin and pyoverdine, virulence factors whose synthesis depends on MvfR.
Formal Description
Interaction-ID: 26806

drug/chemical compound

2-Amino acetophenone, 2-AA

decreases_quantity of

drug/chemical compound

Pyocyanine

Comment 2-amino acetophenone (2-AA) decreased production of pyocyanin and pyoverdine, virulence factors whose synthesis depends on MvfR.
Formal Description
Interaction-ID: 26807

drug/chemical compound

2-Amino acetophenone, 2-AA

decreases_quantity of

drug/chemical compound

Pyoverdine I