General Information:

Id: 2,906 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
CF primary respiratory epithelia, infected with P. aeruginosa strain PAO1
article
Reference: Dechecchi MC et al.(2011) Modulators of sphingolipid metabolism reduce lung inflammation. Am. J. Respir. Cell Mol. Biol. 45: 825-833 [PMID: 21659660]

Interaction Information:

Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26727

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL8

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat