General Information:

Id: 2,906 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
CF primary respiratory epithelia, infected with P. aeruginosa strain PAO1
article
Reference: Dechecchi MC et al.(2011) Modulators of sphingolipid metabolism reduce lung inflammation. Am. J. Respir. Cell Mol. Biol. 45: 825-833 [PMID: 21659660]

Interaction Information:

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26638

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL8

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26644

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL1

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26648

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL2

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26651

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL3

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26654

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL6

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26657

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

ICAM1

Drugbank entries Show/Hide entries for ICAM1
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26659

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

IL1A

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26661

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26662

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

IL6

Drugbank entries Show/Hide entries for IL6
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26667

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26669

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

TLR2

Drugbank entries Show/Hide entries for TLR2
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26670

process

P. aeruginosa infection, chronic

decreases_expression of

gene/protein

TLR5

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26673

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

NFKB1

Drugbank entries Show/Hide entries for NFKB1
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26676

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

HBD-4

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26677

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

DUOX1

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26678

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

DUOX2

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26679

process

P. aeruginosa infection, chronic

increases_activity of