General Information:

Id: 2,906 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
CF primary respiratory epithelia, infected with P. aeruginosa strain PAO1
article
Reference: Dechecchi MC et al.(2011) Modulators of sphingolipid metabolism reduce lung inflammation. Am. J. Respir. Cell Mol. Biol. 45: 825-833 [PMID: 21659660]

Interaction Information:

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26638

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL8

Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26727

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL8

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat