General Information:

Id: 2,906
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
CF primary respiratory epithelia, infected with P. aeruginosa strain PAO1
article
Reference: Dechecchi MC et al.(2011) Modulators of sphingolipid metabolism reduce lung inflammation. Am. J. Respir. Cell Mol. Biol. 45: 825-833 [PMID: 21659660]

Interaction Information:

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26638

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL8

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26644

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL1

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26648

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL2

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26651

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL3

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26654

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

CXCL6

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26657

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

ICAM1

Drugbank entries Show/Hide entries for ICAM1
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26659

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

IL1A

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26661

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26662

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

IL6

Drugbank entries Show/Hide entries for IL6
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26667

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26669

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

TLR2

Drugbank entries Show/Hide entries for TLR2
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26670

process

P. aeruginosa infection, chronic

decreases_expression of

gene/protein

TLR5

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26673

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

NFKB1

Drugbank entries Show/Hide entries for NFKB1
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26676

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

HBD-4

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26677

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

DUOX1

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26678

process

P. aeruginosa infection, chronic

increases_expression of

gene/protein

DUOX2

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 15 (29%) genes in primary CF epithelium, with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26679

process

P. aeruginosa infection, chronic

increases_activity of

Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26683

drug/chemical compound

Miglustat

decreases_activity of

Drugbank entries Show/Hide entries for Miglustat
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26695

drug/chemical compound

Amitriptyline

decreases_activity of

Drugbank entries Show/Hide entries for Amitriptyline
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26727

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL8

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26728

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL1

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26729

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL2

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26730

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL3

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26731

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL6

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26732

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

ICAM1

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or ICAM1
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26733

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

IL1B

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or IL1B
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26734

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

IL6

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or IL6
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26735

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

TLR2

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or TLR2
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26736

drug/chemical compound

Miglustat

increases_expression of

gene/protein

TLR5

down-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment Remarkably, the in vitro data showed an up-modulation by miglustat of HBD-4, an antimicrobial peptide induced by infections or inflammatory stimuli, with strong activity against P. aeruginosa, both in cell lines and primary cells.
Formal Description
Interaction-ID: 26737

drug/chemical compound

Miglustat

increases_expression of

gene/protein

HBD-4

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26739

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

TLR2

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or TLR2
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26740

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

CXCL3

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26741

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

CXCL6

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26742

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

ICAM1

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or ICAM1
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26743

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

IL1B

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or IL1B
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26744

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

IL1B

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or IL1B
Comment Miglustat and amitriptyline are effective in reducing the expression of key genes involved in the inflammatory response, mainly neutrophil chemotaxis, in human bronchial CF epithelial cells infected with P. aeruginosa.
Formal Description
Interaction-ID: 26745

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

IL6

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or IL6
Comment Amitriptyline showed an up-modulation of HBD-4, an antimicrobial peptide induced by infections or inflammatory stimuli, with strong activity against P. aeruginosa in CF primary cells.
Formal Description
Interaction-ID: 26746

drug/chemical compound

Amitriptyline

increases_expression of

gene/protein

HBD-4

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline