General Information:

Id: 2,905 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0004445 IB3-1 cell, human bronchial epithelial cell line, infected with P. aeruginosa strain PAO1
article
Reference: Dechecchi MC et al.(2011) Modulators of sphingolipid metabolism reduce lung inflammation. Am. J. Respir. Cell Mol. Biol. 45: 825-833 [PMID: 21659660]

Interaction Information:

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26666

process

P. aeruginosa infection

increases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26709

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

TNF

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or TNF
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26723

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

TNF

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or TNF