General Information:

Id: 2,905
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0004445 IB3-1 cell, human bronchial epithelial cell line, infected with P. aeruginosa strain PAO1
article
Reference: Dechecchi MC et al.(2011) Modulators of sphingolipid metabolism reduce lung inflammation. Am. J. Respir. Cell Mol. Biol. 45: 825-833 [PMID: 21659660]

Interaction Information:

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26636

process

P. aeruginosa infection

increases_expression of

gene/protein

CXCL8

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26642

process

P. aeruginosa infection

increases_expression of

gene/protein

CXCL1

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26646

process

P. aeruginosa infection

increases_expression of

gene/protein

CXCL2

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26650

process

P. aeruginosa infection

increases_expression of

gene/protein

CXCL3

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26653

process

P. aeruginosa infection

increases_expression of

gene/protein

CXCL6

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26655

process

P. aeruginosa infection

increases_expression of

gene/protein

CXCL10

Drugbank entries Show/Hide entries for CXCL10
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26656

process

P. aeruginosa infection

increases_expression of

gene/protein

ICAM1

Drugbank entries Show/Hide entries for ICAM1
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26658

process

P. aeruginosa infection

increases_expression of

gene/protein

IL1A

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26660

process

P. aeruginosa infection

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26663

process

P. aeruginosa infection

increases_expression of

gene/protein

IL6

Drugbank entries Show/Hide entries for IL6
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26666

process

P. aeruginosa infection

increases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26668

process

P. aeruginosa infection

increases_expression of

gene/protein

TLR2

Drugbank entries Show/Hide entries for TLR2
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26672

process

P. aeruginosa infection

increases_expression of

gene/protein

NFKB1

Drugbank entries Show/Hide entries for NFKB1
Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26674

process

P. aeruginosa infection

increases_expression of

gene/protein

HBD-4

Comment Infection with the P. aeruginosa strain PAO1 for 4 hours up-modulated the expression of 14 (27%) genes in IB3-1 cells with statistically validated transcription levels altered more than 2.0-fold. These genes are involved in the inflammatory response.
Formal Description
Interaction-ID: 26680

process

P. aeruginosa infection

increases_activity of

Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26692

drug/chemical compound

Miglustat

decreases_activity of

Drugbank entries Show/Hide entries for Miglustat
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26694

drug/chemical compound

Amitriptyline

decreases_activity of

Drugbank entries Show/Hide entries for Amitriptyline
Comment The infection with P. aeruginosa increased plasma membrane fluorescent staining, consistent with an accumulation of ceramide because of infection. The expression of ceramide at the cell membrane increased significantly upon infection with P. aeruginosa in both IB3-1 and CuFi-1 cells. Treatment with miglustat and amitriptyline significantly reduced the increase of plasma membrane ceramide expression. This strengthens the link between the anti-inflammatory effects of the two drugs and the modulation of ceramide expression at the plasma membrane of bronchial epithelial cells.
Formal Description
Interaction-ID: 26697

process

P. aeruginosa infection

increases_quantity of

drug/chemical compound

N-Acylsphingosine

at the plasma membrane
Comment The infection with P. aeruginosa increased plasma membrane fluorescent staining, consistent with an accumulation of ceramide because of infection. The expression of ceramide at the cell membrane increased significantly upon infection with P. aeruginosa in both IB3-1 and CuFi-1 cells. Treatment with miglustat and amitriptyline significantly reduced the increase of plasma membrane ceramide expression. This strengthens the link between the anti-inflammatory effects of the two drugs and the modulation of ceramide expression at the plasma membrane of bronchial epithelial cells.
Formal Description
Interaction-ID: 26698

drug/chemical compound

Miglustat

decreases_quantity of

drug/chemical compound

N-Acylsphingosine

at the plasma membrane
Drugbank entries Show/Hide entries for Miglustat
Comment The infection with P. aeruginosa increased plasma membrane fluorescent staining, consistent with an accumulation of ceramide because of infection. The expression of ceramide at the cell membrane increased significantly upon infection with P. aeruginosa in both IB3-1 and CuFi-1 cells. Treatment with miglustat and amitriptyline significantly reduced the increase of plasma membrane ceramide expression. This strengthens the link between the anti-inflammatory effects of the two drugs and the modulation of ceramide expression at the plasma membrane of bronchial epithelial cells.
Formal Description
Interaction-ID: 26699

drug/chemical compound

Amitriptyline

decreases_quantity of

drug/chemical compound

N-Acylsphingosine

at the plasma membrane
Drugbank entries Show/Hide entries for Amitriptyline
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26702

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL8

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26703

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL1

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26704

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL2

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26705

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL3

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26706

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

ICAM1

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or ICAM1
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26707

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

IL1A

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26708

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

IL6

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or IL6
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26709

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

TNF

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or TNF
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26710

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

NFKB1

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat or NFKB1
Comment Remarkably, the in vitro data showed an up-modulation by miglustat of HBD-4, an antimicrobial peptide induced by infections or inflammatory stimuli, with strong activity against P. aeruginosa, both in cell lines and primary cells.
Formal Description
Interaction-ID: 26713

drug/chemical compound

Miglustat

increases_expression of

gene/protein

HBD-4

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26714

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

CXCL8

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26715

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

CXCL1

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26717

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

CXCL3

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26718

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

CXCL6

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26719

drug/chemical compound

Miglustat

decreases_expression of

gene/protein

CXCL6

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Miglustat
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26720

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

ICAM1

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or ICAM1
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26721

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

IL1A

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26722

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

IL1B

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or IL1B
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26723

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

TNF

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or TNF
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26724

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

IL6

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or IL6
Comment The iminosugar miglustat and amitriptyline, a tricyclic antidepressant exert an anti-inflammatory effect in CF bronchial cell lines. The pretreatment of IB3-1 cells with miglustat or amitriptyline reduced the expression of many genes involved in inflammatory response, up-regulated by P. aeruginosa.
Formal Description
Interaction-ID: 26725

drug/chemical compound

Amitriptyline

decreases_expression of

gene/protein

NFKB1

up-regulated by P. aeruginosa
Drugbank entries Show/Hide entries for Amitriptyline or NFKB1