General Information:

Id: 2,853
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/Danio rerio
zebrafish embryos, infected with P. aeruginosa strain P14
article
Reference: Chand NS et al.(2011) The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection J. Bacteriol. 193: 2989-2999 [PMID: 21515773]

Interaction Information:

Comment The authors identified several P. aeruginosa two-component sensors required for virulence in zebrafish embryos. The sensor kinB is reported to regulate alginate biosynthesis in vitro.
Formal Description
Interaction-ID: 26282

gene/protein

kinB

affects_quantity of

cellular component

(alginate)n

Comment The authors identified several P. aeruginosa two-component sensors required for virulence in zebrafish embryos. The sensor phoR is known to regulate the production of rhamnolipids.
Formal Description
Interaction-ID: 26284

gene/protein

phoR

affects_quantity of

cellular component

rhamnolipid

Comment The authors identified several P. aeruginosa two-component sensors required for virulence in zebrafish embryos. The sensor copS is known as a copper ion sensor.
Formal Description
Interaction-ID: 26290

gene/protein

copS

affects_activity of

Comment The authors identified several P. aeruginosa two-component sensors required for virulence in zebrafish embryos. The sensor bqsS is known to play a role in biofilm formation.
Formal Description
Interaction-ID: 26292

gene/protein

bqsS

affects_activity of

Comment KinB appears to modulate the production of the quorum-sensing-regulated virulence factors pyocyanin and elastase without significantly affecting the production of the quorum sensing autoinducer molecules (3OC12-HSL, C4-HSL) themselves, and in a manner independent of AlgB.
Formal Description
Interaction-ID: 26293

gene/protein

kinB

increases_quantity of

drug/chemical compound

Pyocyanine

in a manner independent of AlgB
Comment KinB appears to modulate the production of the quorum-sensing-regulated virulence factors pyocyanin and elastase without significantly affecting the production of the quorum sensing autoinducer molecules (3OC12-HSL, C4-HSL) themselves, and in a manner independent of AlgB.
Formal Description
Interaction-ID: 26294

gene/protein

kinB

increases_quantity of

gene/protein

lasB

in a manner independent of AlgB
Drugbank entries Show/Hide entries for lasB
Comment KinB appears to modulate the production of the quorum-sensing-regulated virulence factors pyocyanin and elastase without significantly affecting the production of the quorum sensing autoinducer molecules (3OC12-HSL, C4-HSL) themselves.
Formal Description
Interaction-ID: 26295

gene/protein

kinB

NOT increases_quantity of

drug/chemical compound

N-(3-Oxododecanoyl)-HSL

Comment KinB appears to modulate the production of the quorum-sensing-regulated virulence factors pyocyanin and elastase without significantly affecting the production of the quorum sensing autoinducer molecules (3OC12-HSL, C4-HSL) themselves.
Formal Description
Interaction-ID: 26296

gene/protein

kinB

NOT increases_quantity of

drug/chemical compound

N-Butyryl-HSL

Comment KinB is required for acute infection in zebrafish embryos.
Formal Description
Interaction-ID: 26299

gene/protein

kinB

increases_activity of

process

P. aeruginosa infection, acute

Comment KinB does not play a role in the modulation of T3S-dependent cytotoxicity.
Formal Description
Interaction-ID: 26300

gene/protein

kinB

NOT affects_activity of

process

T3SS

Comment KinB regulates biofilm formation.
Formal Description
Interaction-ID: 26301

gene/protein

kinB

affects_activity of

Comment The sensor copS is known as a copper ion sensor. It has been shown that CopR expression is downregulated during mouse burn infections and that CopR participates in the regulation of type III secretion through control of ptrA.
Formal Description
Interaction-ID: 29743

gene/protein

copS

increases_activity of

gene/protein

copR

Comment The sensor copS is known as a copper ion sensor. It has been shown that CopR expression is downregulated during mouse burn infections and that CopR participates in the regulation of type III secretion through control of ptrA.
Formal Description
Interaction-ID: 29744

process

P. aeruginosa infection

decreases_expression of

gene/protein

copR

Comment The sensor copS is known as a copper ion sensor. It has been shown that CopR expression is downregulated during mouse burn infections and that CopR participates in the regulation of type III secretion through control of ptrA.
Formal Description
Interaction-ID: 29745

gene/protein

copR

affects_activity of

gene/protein

ptrA