General Information:

Id: 2,818 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
WT C57BL/6 mice, infected with P. aeruginosa strain PAO1
article
Reference: Wu M et al.(2011) Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice. Infect. Immun. 79: 75-87 [PMID: 20956573]

Interaction Information:

Comment To define the physiological relevance of OGG1-mediated DNA repair, it was shown that P. aeruginosa strain PAO1 infection of mice induced a DNA repair response in lungs compared to saline controls.
Formal Description
Interaction-ID: 25972

process

P. aeruginosa infection

increases_activity of

in mouse lungs
Comment The expression of various DNA repair proteins was verified in WT C57BL/6 mice by immunochemical analysis, where no-infection controls showed no increase in the expression of either OGG1 or XRCC1. However, PAO1 infection induced an increase in both OGG1 and XRCC1 (approximately 3.9-fold for each) in the lung.
Formal Description
Interaction-ID: 25976

process

P. aeruginosa infection

increases_quantity of

gene/protein

OGG1

in mouse lungs
Comment The expression of various DNA repair proteins was verified in WT C57BL/6 mice by immunochemical analysis, where no-infection controls showed no increase in the expression of either OGG1 or XRCC1. However, PAO1 infection induced an increase in both OGG1 and XRCC1 (approximately 3.9-fold for each) in the lung.
Formal Description
Interaction-ID: 25978

process

P. aeruginosa infection

increases_quantity of

gene/protein

XRCC1

in mouse lungs