General Information:

Id: 2,813 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000018 A-549 cell, infected with P. aeruginosa strain PAO1
article
Reference: Wu M et al.(2011) Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice. Infect. Immun. 79: 75-87 [PMID: 20956573]

Interaction Information:

Comment siRNA-induced knock down of OGG1 corresponded with an increase in DNA damage due to PAO1 infection. There was a greater cytotoxicity in OGG1 siRNA-transfected cells than in control cells, suggesting that OGG1 may play a key role in counteracting bacterium-induced cytotoxic effects.
Formal Description
Interaction-ID: 25968

gene/protein

OGG1

decreases_activity of

process

P. aeruginosa infection