General Information:

Id: 2,813 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000018 A-549 cell, infected with P. aeruginosa strain PAO1
article
Reference: Wu M et al.(2011) Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice. Infect. Immun. 79: 75-87 [PMID: 20956573]

Interaction Information:

Comment P. aeruginosa infection causes a commonly induced DNA damage adduct-oxoG (7,8-dihydro-8-oxoguanine). OxoG is the most common form of oxidative DNA adduct and tends to mispair with the base A (adenine), leading to a mutagenic transversion of GC to TA.
Formal Description
Interaction-ID: 25924

process

P. aeruginosa infection

increases_quantity of

drug/chemical compound

7,8-Dihydro-8-oxoguanine