General Information:

Id: 2,813 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000018 A-549 cell, infected with P. aeruginosa strain PAO1
article
Reference: Wu M et al.(2011) Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice. Infect. Immun. 79: 75-87 [PMID: 20956573]

Interaction Information:

Comment The study demonstrates that P. aeruginosa infection causes severe DNA damage, which subsequently activates a group of DNA repair proteins (OGG1, APE1, and CSB).
Formal Description
Interaction-ID: 25923

process

P. aeruginosa infection

increases_activity of

Comment P. aeruginosa infection causes a commonly induced DNA damage adduct-oxoG (7,8-dihydro-8-oxoguanine). OxoG is the most common form of oxidative DNA adduct and tends to mispair with the base A (adenine), leading to a mutagenic transversion of GC to TA.
Formal Description
Interaction-ID: 25924

process

P. aeruginosa infection

increases_quantity of

drug/chemical compound

7,8-Dihydro-8-oxoguanine

Comment The study demonstrates that P. aeruginosa infection causes severe DNA damage, which subsequently activates a group of DNA repair proteins OGG1, APE1, and CSB.
Formal Description
Interaction-ID: 25927

process

P. aeruginosa infection

increases_activity of

gene/protein

OGG1

Comment The study demonstrates that P. aeruginosa infection causes severe DNA damage, which subsequently activates a group of DNA repair proteins OGG1, APE1, and CSB.
Formal Description
Interaction-ID: 25928

process

P. aeruginosa infection

increases_activity of

gene/protein

APEX1

Drugbank entries Show/Hide entries for APEX1
Comment The study demonstrates that P. aeruginosa infection causes severe DNA damage, which subsequently activates a group of DNA repair proteins OGG1, APE1, and CSB.
Formal Description
Interaction-ID: 25929

process

P. aeruginosa infection

increases_activity of

gene/protein

ERCC6

Comment OGG1 activity upon P. aeruginosa infection was significantly greater, 5-fold, than that in the controls. The expression of OGG1 was increased by more than 6-fold over the control as measured 1 h after P. aeruginosa infection.
Formal Description
Interaction-ID: 25930

process

P. aeruginosa infection

increases_quantity of

gene/protein

OGG1

Comment Because live P. aeruginosa strain PAO1 bacteria induced higher levels of APE1 and CSB expression, these two repair proteins may significantly contribute to the in vivo host defense.
Formal Description
Interaction-ID: 25949

process

P. aeruginosa infection

increases_quantity of

gene/protein

APEX1

Drugbank entries Show/Hide entries for APEX1
Comment Because live P. aeruginosa strain PAO1 bacteria induced higher levels of APE1 and CSB expression, these two repair proteins may significantly contribute to the in vivo host defense.
Formal Description
Interaction-ID: 25964

process

P. aeruginosa infection

increases_quantity of

gene/protein

ERCC6

Comment siRNA-induced knock down of OGG1 corresponded with an increase in DNA damage due to PAO1 infection. There was a greater cytotoxicity in OGG1 siRNA-transfected cells than in control cells, suggesting that OGG1 may play a key role in counteracting bacterium-induced cytotoxic effects.
Formal Description
Interaction-ID: 25968

gene/protein

OGG1

decreases_activity of

process

P. aeruginosa infection