General Information:

Id: 2,812 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0002734 16-HBE14o cell, infected with P. aeruginosa strain PA3
article
Reference: Cuzick A et al.(2006) The type III pseudomonal exotoxin U activates the c-Jun NH2-terminal kinase pathway and increases human epithelial interleukin-8 production. Infect. Immun. 74: 4104-4113 [PMID: 16790784]

Interaction Information:

Comment It was shown that ExoU produces activation of the c-Jun NH2-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathway and that this is required for efficient IL-8 production following infection.
Formal Description
Interaction-ID: 25918

process

MAPK cascade

increases_quantity of

gene/protein

CXCL8

in respiratory epithelial cells