General Information:

Id: 2,812 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0002734 16-HBE14o cell, infected with P. aeruginosa strain PA3
article
Reference: Cuzick A et al.(2006) The type III pseudomonal exotoxin U activates the c-Jun NH2-terminal kinase pathway and increases human epithelial interleukin-8 production. Infect. Immun. 74: 4104-4113 [PMID: 16790784]

Interaction Information:

Comment ExoU is the factor responsible for the production of IL-8 in respiratory epithelial cells following infection with P. aeruginosa. The increase in IL-8 produced by ExoU is dependent on the catalytic lipase activity of the protein.
Formal Description
Interaction-ID: 25908

gene/protein

exoU

increases_quantity of

gene/protein

CXCL8

in respiratory epithelial cells