General Information:

Id: 2,805 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
mice macrophages, infected with P. aeruginosa strain PA103 (expressing ExoU and ExoT)
article
Reference: Sutterwala FS et al.(2007) Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J. Exp. Med. 204: 3235-3245 [PMID: 18070936]

Interaction Information:

Comment ExoU induces macrophage cell death independently of IPAF.
Formal Description
Interaction-ID: 25873

gene/protein

exoU

increases_activity of

process

cell death

in macrophages; infected with P. aeruginosa strain PA103 (expressing ExoU)
Comment ExoU inhibits caspase-1 activation and secretion of IL-1beta. P. aeruginosa ExoU phospholipase activity is required for inhibition of caspase-1 activation.
Formal Description
Interaction-ID: 25878

gene/protein

exoU

decreases_activity of

gene/protein

CASP1

in macrophages; infected with P. aeruginosa strain PA103 (expressing ExoU)
Drugbank entries Show/Hide entries for CASP1
Comment ExoU inhibits caspase-1 activation and secretion of IL-1beta. In an P. aeruginosa peritonitis model it was shown that caspase-1-driven cytokines IL-1beta and IL-18 were both significantly higher in serum from mice infected with PA103-deltaU compared with PA103, recapitulating in vivo the in vitro finding that ExoU is capable of inhibiting caspase-1 activation.
Formal Description
Interaction-ID: 25879

gene/protein

exoU

decreases_quantity of

gene/protein

IL1B

in macrophages; infected with P. aeruginosa strain PA103 (expressing ExoU)
Drugbank entries Show/Hide entries for IL1B
Comment In an P. aeruginosa peritonitis model it was shown that caspase-1-driven cytokines IL-1beta and IL-18 were both significantly higher in serum from mice infected with PA103-deltaU compared with PA103, recapitulating in vivo the in vitro finding that ExoU is capable of inhibiting caspase-1 activation.
Formal Description
Interaction-ID: 25881

gene/protein

exoU

decreases_quantity of

gene/protein

IL18

in macrophages; infected with P. aeruginosa strain PA103 (expressing ExoU)