General Information:

Id: 2,802 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
mice macrophages, infected with P. aeruginosa strain PAK (ExoU deficient)
Reference: Sutterwala FS et al.(2007) Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J. Exp. Med. 204: 3235-3245 [PMID: 18070936]

Interaction Information:

Comment ExoU-deficient strains of P. aeruginosa kill macrophages in an IPAF/caspase-1 dependent manner that also results in the secretion of caspase-1 driven proinflammatory cytokines.
Formal Description
Interaction-ID: 25857


P. aeruginosa infection

increases_activity of


cell death

in macrophages; infected with P. aeruginosa strain PAK (ExoU deficient)