General Information:

Id: 2,792 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000018 A-549 cell; BTO:0001370THP-1 cell, both infected with P. aeruginosa strain PA103
article
Reference: Machado GB et al.(2011) Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. Respir. Res. 12: 104 [PMID: 21819560]

Interaction Information:

Comment ExoU-induced PAI-1 overexpression was likely dependent on the PAF signaling system. The cell treatment with an anti-PAFR antibody prior to PA103 infection resulted in a significant reduction of both PAI-1 mRNA expression and PAI-1 concentration in cell culture supernatants, supporting the contribution of the PAF signaling system in the ExoU-induced antifibrinolytic environment in mice airways.
Formal Description
Interaction-ID: 25822

gene/protein

exoU

affects_activity of

process

PAF signaling system