Machado GB et al.(2011) Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. Respir. Res. 12: 104
ExoU modulated PAI-1 release by both airway epithelial cells and macrophages. PAI-1 concentrations in supernatants from A549 epithelial respiratory cells and THP-1 macrophages infected with the ExoU-producing PA103 were significantly higher than concentrations detected in supernatants from control noninfected cells or from cells infected with the PA103 exoU mutant.
Disclaimer: MIPS Databases and associated information are protected by copyright. This server and its associated data and
services are for academic, non-commercial use only. The Helmholtz Zentrum München has no liability for the use of results, data
or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of
MIPS database files to third parties nor the distribution of parts of files or derivative products to any third parties is