Machado GB et al.(2011) Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. Respir. Res. 12: 104
ExoU modulated PAI-1 release by both airway epithelial cells and macrophages. PAI-1 concentrations in supernatants from A549 epithelial respiratory cells and THP-1 macrophages infected with the ExoU-producing PA103 were significantly higher than concentrations detected in supernatants from control noninfected cells or from cells infected with the PA103 exoU mutant.
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