General Information:

Id: 2,792 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000018 A-549 cell; BTO:0001370THP-1 cell, both infected with P. aeruginosa strain PA103
article
Reference: Machado GB et al.(2011) Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. Respir. Res. 12: 104 [PMID: 21819560]

Interaction Information:

Comment ExoU modulated PAI-1 release by both airway epithelial cells and macrophages. PAI-1 concentrations in supernatants from A549 epithelial respiratory cells and THP-1 macrophages infected with the ExoU-producing PA103 were significantly higher than concentrations detected in supernatants from control noninfected cells or from cells infected with the PA103 exoU mutant.
Formal Description
Interaction-ID: 25819

gene/protein

exoU

increases_quantity of

gene/protein

SERPINE1

Drugbank entries Show/Hide entries for SERPINE1
Comment ExoU modulated PAI-1 release by both airway epithelial cells and macrophages. The level of PAI-1 mRNA in PA103-infected cells was about 20% higher, in comparison with PA103 delta-exoU-infected cells.
Formal Description
Interaction-ID: 25820

gene/protein

exoU

increases_expression of

gene/protein

SERPINE1

Drugbank entries Show/Hide entries for SERPINE1
Comment ExoU-induced PAI-1 overexpression was likely dependent on the PAF signaling system. The cell treatment with an anti-PAFR antibody prior to PA103 infection resulted in a significant reduction of both PAI-1 mRNA expression and PAI-1 concentration in cell culture supernatants, supporting the contribution of the PAF signaling system in the ExoU-induced antifibrinolytic environment in mice airways.
Formal Description
Interaction-ID: 25822

gene/protein

exoU

affects_activity of

process

PAF signaling system