General Information:

Id: 2,791
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Recovered bronchoalveolar lavage fluids (BALF) of mice infected with P. aeruginosa strain PA103 (ExoU-producing)
article
Reference: Machado GB et al.(2011) Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. Respir. Res. 12: 104 [PMID: 21819560]

Interaction Information:

Comment ExoU induced a robust inflammatory response in mice airways. Concentrations of total white blood cells, IL-6 and TNF-alpha in BALF (bronchoalveolar lavage fluids) from PA103-infected mice were significantly higher than in noninfected mice and from mice infected with the PA103 delta-exoU mutant.
Formal Description
Interaction-ID: 25815

gene/protein

exoU

increases_activity of

Comment ExoU induced a robust inflammatory response in mice airways. Concentrations of total white blood cells, IL-6 and TNF-alpha in BALF (bronchoalveolar lavage fluids) from PA103-infected mice were significantly higher than in noninfected mice and from mice infected with the PA103 delta-exoU mutant.
Formal Description
Interaction-ID: 25816

gene/protein

exoU

increases_quantity of

gene/protein

IL6

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Comment ExoU induced a robust inflammatory response in mice airways. Concentrations of total white blood cells, IL-6 and TNF-alpha in BALF (bronchoalveolar lavage fluids) from PA103-infected mice were significantly higher than in noninfected mice and from mice infected with the PA103 delta-exoU mutant.
Formal Description
Interaction-ID: 25817

gene/protein

exoU

increases_quantity of

gene/protein

TNF

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Comment ExoU induced a procoagulant and antifibrinolytic environment in mice airways.
Formal Description
Interaction-ID: 25818

gene/protein

exoU

affects_activity of

Comment ExoU-induced PAI-1 overexpression was likely dependent on the PAF signaling system. Mice treatment with the PAF antagonist WEB-2086 reduced significantly the concentrations of PAI-1 and of inflammatory cells, as well as the procoagulant activity detected in BALF from mice infected with the ExoU-producing PA103 bacteria.
Formal Description
Interaction-ID: 25821

gene/protein

exoU

affects_activity of

process

PAF signaling system

Comment ExoU-induced PAI-1 overexpression was likely dependent on the PAF signaling system. Mice treatment with the PAF antagonist WEB-2086 reduced significantly the concentrations of PAI-1 and of inflammatory cells, as well as the procoagulant activity detected in BALF from mice infected with the ExoU-producing PA103 bacteria.
Formal Description
Interaction-ID: 25823

process

PAF signaling system

affects_quantity of

gene/protein

SERPINE1

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