General Information:

Id: 2,790 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
murine lung epithelial cells, infected with P. aeruginosa strain PA103
article
Reference: Chen BB et al.(2011) Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis. Mol. Cell. Biol. 31: 1905-1920 [PMID: 21343341]

Interaction Information:

Comment P. aeruginosa PA103 triggers Ca2+ influx in murine lung epithelia.
Formal Description
Interaction-ID: 25800

process

P. aeruginosa infection

increases_quantity of

drug/chemical compound

Ca2+

in lung epithelia
Comment P. aeruginosa triggers calcium influx and calcium-dependent activation of FBXL2.
Formal Description
Interaction-ID: 25804

process

P. aeruginosa infection

increases_activity of

gene/protein

FBXL2

Comment The observations indicate that pulmonary expression of CaM can partially improve inflammation or preserve lung mechanics in the setting of P. aeruginosa infection.
Formal Description
Interaction-ID: 25813

gene/protein

CALM1

decreases_activity of

process

P. aeruginosa infection

Drugbank entries Show/Hide entries for CALM1