General Information:

Id: 2,781
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
article/cited
Reference: Schweizer HP and Choi KH(2011) Pseudomonas aeruginosa aerobic fatty acid desaturase DesB is important for virulence factor production. Arch. Microbiol. 193: 227-234 [PMID: 21184216]

Interaction Information:

Comment Elastin degradation by the concerted activity of both P. aeruginosa LasB and LasA elastases is regarded as a major virulence determinant during acute infection, thus causing pulmonary hemorrhages during invasive P. aeruginosa infections. (cited information)
Formal Description
Interaction-ID: 25713

gene/protein

lasA

decreases_quantity of

gene/protein

ELN

Drugbank entries Show/Hide entries for ELN
Comment Elastin degradation by the concerted activity of both P. aeruginosa LasB and LasA elastases is regarded as a major virulence determinant during acute infection, thus causing pulmonary hemorrhages during invasive P. aeruginosa infections. (cited information)
Formal Description
Interaction-ID: 25714

gene/protein

lasB

decreases_quantity of

gene/protein

ELN

Drugbank entries Show/Hide entries for lasB or ELN
Comment The following genes and proteins are involved in P. aeruginosa UFA (unsaturated fatty acids) synthesis, desA, fabB, fabA, desB, desC, desT. (cited information)
Formal Description
Interaction-ID: 25715

gene/protein

desA

affects_activity of

Comment The following genes and proteins are involved in P. aeruginosa UFA (unsaturated fatty acids) synthesis, desA, fabB, fabA, desB, desC, desT. (cited information)
Formal Description
Interaction-ID: 25716

gene/protein

fabB

affects_activity of

Drugbank entries Show/Hide entries for fabB
Comment The following genes and proteins are involved in P. aeruginosa UFA (unsaturated fatty acids) synthesis, desA, fabB, fabA, desB, desC, desT. (cited information)
Formal Description
Interaction-ID: 25717

gene/protein

fabA

affects_activity of

Drugbank entries Show/Hide entries for fabA
Comment The following genes and proteins are involved in P. aeruginosa UFA (unsaturated fatty acids) synthesis, desA, fabB, fabA, desB, desC, desT. (cited information)
Formal Description
Interaction-ID: 25718

gene/protein

desB

affects_activity of

Comment The following genes and proteins are involved in P. aeruginosa UFA (unsaturated fatty acids) synthesis, desA, fabB, fabA, desB, desC, desT. (cited information)
Formal Description
Interaction-ID: 25719

gene/protein

desC

affects_activity of

Comment The following genes and proteins are involved in P. aeruginosa UFA (unsaturated fatty acids) synthesis, desA, fabB, fabA, desB, desC, desT. (cited information)
Formal Description
Interaction-ID: 25720

gene/protein

desT

affects_activity of

Comment Pyocyanin, produced by P. aeruginosa is the major phenazine excreted by this organism and inhibits the acute inflammatory response through bacterial pathogen-mediated stimulation of neutrophil apoptosis, resulting in bacterial survival. (cited information)
Formal Description
Interaction-ID: 25726

drug/chemical compound

Pyocyanine

increases_activity of

Comment Elastin degradation by the concerted activity of both P. aeruginosa LasB and LasA elastases is regarded as a major virulence determinant during acute infection, thus causing pulmonary hemorrhages during invasive P. aeruginosa infections. (cited information)
Formal Description
Interaction-ID: 33888

process

P. aeruginosa infection, acute

increases_activity of

gene/protein

lasA

Comment Elastin degradation by the concerted activity of both P. aeruginosa LasB and LasA elastases is regarded as a major virulence determinant during acute infection, thus causing pulmonary hemorrhages during invasive P. aeruginosa infections. (cited information)
Formal Description
Interaction-ID: 33889

process

P. aeruginosa infection, acute

increases_activity of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment Elastin degradation by the concerted activity of both P. aeruginosa LasB and LasA elastases is regarded as a major virulence determinant during acute infection, thus causing pulmonary hemorrhages during invasive P. aeruginosa infections. (cited information)
Formal Description
Interaction-ID: 40198

gene/protein

lasA

increases_activity of

phenotype

lung hemorrhage

Comment Elastin degradation by the concerted activity of both P. aeruginosa LasB and LasA elastases is regarded as a major virulence determinant during acute infection, thus causing pulmonary hemorrhages during invasive P. aeruginosa infections. (cited information)
Formal Description
Interaction-ID: 40199

gene/protein

lasB

increases_activity of

phenotype

lung hemorrhage

Drugbank entries Show/Hide entries for lasB