General Information:

Id: 2,745 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000018 A-549 cell, infected with P. aeruginosa strain PAO1
Reference: Hurley BP et al.(2011) Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 300: L286-L294 [PMID: 21097525]

Interaction Information:

Comment Treatment of A549 cells with PAO1 results in an approximately fourfold increase in secretion of PGE2 after a 3-h infection, demonstrating that multiple eicosanoids (PGE2 as well as the previously reported HXA3) are produced by lung epithelial cells in response to infection with P. aeruginosa.
Formal Description
Interaction-ID: 25404


P. aeruginosa infection

increases_quantity of

drug/chemical compound

Prostaglandin E2

in A549 cells; after 3 h infection