General Information:

Id: 2,745 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000018 A-549 cell, infected with P. aeruginosa strain PAO1
article
Reference: Hurley BP et al.(2011) Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 300: L286-L294 [PMID: 21097525]

Interaction Information:

Comment Treatment of A549 cells with PAO1 results in an approximately fourfold increase in secretion of PGE2 after a 3-h infection, demonstrating that multiple eicosanoids (PGE2 as well as the previously reported HXA3) are produced by lung epithelial cells in response to infection with P. aeruginosa.
Formal Description
Interaction-ID: 25404

process

P. aeruginosa infection

increases_quantity of

drug/chemical compound

Prostaglandin E2

in A549 cells; after 3 h infection
Comment Treatment of A549 cells with PAO1 results in an approximately fourfold increase in secretion of PGE2 after a 3-h infection, demonstrating that multiple eicosanoids (PGE2 as well as the previously reported HXA3) are produced by lung epithelial cells in response to infection with P. aeruginosa.
Formal Description
Interaction-ID: 25405

process

P. aeruginosa infection

increases_quantity of

drug/chemical compound

Hepoxilin A3

in A549 cells; after 3 h infection
Comment The infection of lung epithelial cells with P. aeruginosa results in increased release of AA (arachidonic acid), the common precursor of HXA3 (hepoxilin A3) and PGE2 (Prostaglandin E2).
Formal Description
Interaction-ID: 25406

process

P. aeruginosa infection

increases_quantity of

drug/chemical compound

Arachidonic acid

Drugbank entries Show/Hide entries for
Comment Treatment of A549 cells with either PMA or PAO1 results in a noticeable increase in expression of the phosphorylated form of cPLA2-alpha, while the overall cPLA2-alpha expression levels remain unchanged.
Formal Description
Interaction-ID: 25414

process

P. aeruginosa infection

increases_activity of

gene/protein

PLA2G4A

by phosphorylation
Drugbank entries Show/Hide entries for PLA2G4A