General Information:

Id: 2,742 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000018 A-549 cell, infected with P. aeruginosa strain PAK or PAO1
article
Reference: Shin HS and Ha UH(2011) Up-regulation of human bradykinin B1 receptor by secreted components of Pseudomonas aeruginosa via a NF-kappaB pathway in epithelial cells. FEMS Immunol. Med. Microbiol. 63: 418-426 [PMID: 22092568]

Interaction Information:

Comment Pseudomonas aeruginosa up-regulates the expression of hB1R mRNA. The ability to induce hB1R is well conserved among P. aeruginosa strains, and the optimal induction was observed 4 h post treatment at an MOI (multiplicity of infection) of 10.
Formal Description
Interaction-ID: 25395

process

P. aeruginosa infection

increases_expression of

gene/protein

BDKRB1

in airway epithelial A549 cells; optimum reached at 4 h post treatment at an MOI of 10
Comment Consistent with hB1R mRNA induction, the cell ELISA analysis revealed that hB1R protein production increased in response to PAK Lys (lysate).
Formal Description
Interaction-ID: 25397

process

P. aeruginosa infection

increases_quantity of

gene/protein

BDKRB1

in airway epithelial A549 cells; 4 h post treatment
Comment Pseudomonas aeruginosa induces the expression of hB1R via NF-kappaB pathway. Pseudomonas aeruginosa infection is known to contribute to the activation of NF-kappaB.
Formal Description
Interaction-ID: 25400

process

P. aeruginosa infection

increases_activity of