General Information:

Id: 2,695
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0002828 HMEC-1 cell, infected with P. aeruginosa strain PA103
article
Reference: Lins RX et al.(2010) ExoU modulates soluble and membrane-bound ICAM-1 in Pseudomonas aeruginosa-infected endothelial cells. Microbes Infect. 12: 154-161 [PMID: 19931407]

Interaction Information:

Comment PLA(2) (phospholipase A(2)) activity of ExoU down-regulates membrane-bound mICAM-1 expression and up-regulates soluble sICAM-1 release in P. aeruginosa-infected endothelial cells.
Formal Description
Interaction-ID: 25179

gene/protein

exoU

decreases_quantity of

gene/protein

ICAM1, membrane-bound

Comment PLA(2) (phospholipase A(2)) activity of ExoU down-regulates membrane-bound mICAM-1 expression and up-regulates soluble sICAM-1 release in P. aeruginosa-infected endothelial cells.
Formal Description
Interaction-ID: 25189

gene/protein

exoU

increases_quantity of

gene/protein

ICAM1, soluble

Comment No differences in mICAM-1 and sICAM-1 mRNA levels were observed when cultures were infected with the ExoU-producing PA103 strain or the mutant PA103-Delta-exoU.
Formal Description
Interaction-ID: 25190

gene/protein

exoU

NOT affects_expression of

gene/protein

ICAM1, membrane-bound

Comment No differences in mICAM-1 and sICAM-1 mRNA levels were observed when cultures were infected with the ExoU-producing PA103 strain or the mutant PA103-Delta-exoU.
Formal Description
Interaction-ID: 25191

gene/protein

exoU

NOT affects_expression of

gene/protein

ICAM1, soluble

Comment The authors suggest that, although the direct effect of ExoU PLA(2) activity has resulted in the COX-dependent mICAM-1 partial cleavage, the levels of this adhesion molecule expressed on the endothelial cell surface were sufficient to promote the recruitment of leukocytes.
Formal Description
Interaction-ID: 25198

gene/protein

ICAM1, membrane-bound

affects_activity of

Comment The authors suggest that, sICAM-1 release may thus contribute to disease severity in infections caused by ExoU-producing P. aeruginosa strains, by intensifying the inflammatory reaction and participating in the endothelial damage that favors bacterial dissemination.
Formal Description
Interaction-ID: 25199

gene/protein

ICAM1, soluble

affects_activity of