General Information:

Id: 2,665
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000567 HeLa cell, infected with P. aeruginosa strain PA4
article
Reference: Stirling FR et al.(2006) Eukaryotic localization, activation and ubiquitinylation of a bacterial type III secreted toxin. Cell. Microbiol. 8: 1294-1309 [PMID: 16882033]

Interaction Information:

Comment ExoU undergoes modification within the cell by addition of two ubiquitin molecules at lysine-178. The addition of the ubiquitin residues to ExoU is not the cause of plasma membrane localization, but rather seems to be the result of the protein trafficking to this location.
Formal Description
Interaction-ID: 25090

gene/protein

UBB

interacts (colocalizes) with

gene/protein

exoU

Drugbank entries Show/Hide entries for UBB
Comment ExoU is localized to the plasma membrane, analyzed in HeLa cells. Localization of the phospholipase ExoU to the plasma membrane is thus required for activation and allows efficient utilization of adjacent substrate phospholipids.
Formal Description
Interaction-ID: 25094

gene/protein

exoU

is localized in

cellular component

host cell plasma membrane