General Information:

Id: 2,613 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
BTO:0000018 A-549 cell, infected with P. aeruginosa strain PAK or strain PAO1
article
Reference: Shin HS and Ha UH(2011) Up-regulation of bradykinin B2 receptor by Pseudomonas aeruginosa via the NF-kappaB pathway. Curr. Microbiol. 63: 138-144 [PMID: 21626144]

Interaction Information:

Comment P. aeruginosa strains PAK and PAO1 induce hB2R expression, and optimal induction was observed 4 h post treatment at a MOI (multiplicity of infection) of 10.
Formal Description
Interaction-ID: 24783

process

P. aeruginosa infection

increases_expression of

gene/protein

BDKRB2

Drugbank entries Show/Hide entries for BDKRB2
Comment Consistent with hB2R mRNA induction, immunoblotting analysis revealed increased hB2R protein production in response to PAK lysate by 4 h post treatment.
Formal Description
Interaction-ID: 24791

process

P. aeruginosa infection

increases_quantity of

gene/protein

BDKRB2

Drugbank entries Show/Hide entries for BDKRB2
Comment Infection of Pseudomonas aeruginosa has been shown to stimulate the production of bradykinin (BK), which is known as a universal mediator for the induction of inflammatory reaction via the predominant interaction with the bradykinin B2 receptor (B2R).
Formal Description
Interaction-ID: 24794

process

P. aeruginosa infection

increases_quantity of

gene/protein

Bradykinin

Comment P. aeruginosa is able to up-regulate the expression of B2R during infection via the NF-kappaB signaling pathway.
Formal Description
Interaction-ID: 24834

process

P. aeruginosa infection

increases_activity of