General Information:

Id: 2,612 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa / Drosophila melanogaster
P. aeruginosa strain PA14 in an oral infection model of Drosophila melanogaster
article
Reference: Limmer S et al.(2011) Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model. Proc. Natl. Acad. Sci. U.S.A. 108 [PMID: 21987808]

Interaction Information:

Comment RhlR, but not the LasR acylhomoserine lactone quorum-sensing transcription factor, is required for the virulence of orally ingested P. aeruginosa PA14. Several independent PA14 rhlR mutants, which are deficient for the C4-acylhomoserine lactone-dependent quorum-sensing regulator RhlR, a second acylhomoserine lactone quorum-sensing system in P. aeruginosa, were severely impaired in virulence and killed the flies 3-4 d later than wild-type PA14.
Formal Description
Interaction-ID: 24761

gene/protein

lasR

NOT affects_activity of

process

P. aeruginosa infection

in a Drosophila melanogaster oral infection model
Drugbank entries Show/Hide entries for lasR