General Information:

Id: 2,592 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Moscoso JA et al.(2011) The Pseudomonas aeruginosa sensor RetS switches type III and type VI secretion via c-di-GMP signalling Environ. Microbiol. 13: 3128-3138 [PMID: 21955777]

Interaction Information:

Comment P. aeruginosa chronic infections are a major burden and cause of mortality in people suffering from cystic fibrosis (CF). In the CF lungs, the bacteria establish as a biofilm, which is difficult to eradicate by the immune system or antibiotic therapy. Previous reports suggest that P. aeruginosa chronic infections are associated with expression of the type VI secretion system (T6SS).
Formal Description
Interaction-ID: 24456

process

P. aeruginosa infection, chronic

increases_activity of

in patients with CF
Comment RsmA directly repress the transcripts of the pel and psl genes that are important in biofilm development. The pel genes are proposed to encode a yet uncharacterized exopolysaccharide, while the psl gene products direct the synthesis of a repeating pentasaccharide containing d-mannose, d-glucose and d-rhamnose. Both exopolysaccharides contribute to the biofilm architecture.
Formal Description
Interaction-ID: 24476

cellular component

pel-exopolysaccharide

increases_activity of

Comment The second messenger c-di-GMP is utilized as a signal for transition between the planktonic and sessile lifestyles. High c-di-GMP levels promote biofilm formation and chronic infections, while low c-di-GMP levels favour swimming and virulence.
Formal Description
Interaction-ID: 24481

drug/chemical compound

cdiGMP

increases_activity of

if c-di-GMP level is high
Comment RsmA directly repress the transcripts of the pel and psl genes that are important in biofilm development. The pel genes are proposed to encode a yet uncharacterized exopolysaccharide, while the psl gene products direct the synthesis of a repeating pentasaccharide containing d-mannose, d-glucose and d-rhamnose. Both exopolysaccharides contribute to the biofilm architecture.
Formal Description
Interaction-ID: 30044

cellular component

psl-exopolysaccharide

increases_activity of