General Information:

Id: 2,586 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Diaz MR et al.(2011) Intrinsic and Extrinsic Regulation of Type III Secretion Gene Expression in Pseudomonas Aeruginosa. Front Microbiol 2: 89 [PMID: 21833328]

Interaction Information:

Comment The P. aeruginosa type III secretion system (T3SS) contributes to virulence in ameba, insect, zebrafish, and mammalian infection models and protects P. aeruginosa from phagocytosis irrespective of whether the phagocyte is an ameba or a human macrophage.
Formal Description
Interaction-ID: 24363

process

P. aeruginosa infection

increases_activity of

process

T3SS

in ameba, insect, zebrafish, and mammalian infection models
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24364

process

T3SS

increases_transport of

gene/protein

exoS

into the host cell
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24365

process

T3SS

increases_transport of

gene/protein

exoT

into the host cell
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24366

process

T3SS

increases_transport of

gene/protein

exoU

into the host cell
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24367

process

T3SS

increases_transport of

gene/protein

exoY

into the host cell
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24368

process

T3SS

increases_transport of

gene/protein

fliC

into the host cell
Comment The T3SS translocated effectors facilitate phagocytic avoidance, tissue invasion and systemic spread, and modulate the inflammatory response.
Formal Description
Interaction-ID: 24369

process

T3SS

decreases_activity of

process

phagocytosis

Comment Low Ca2+, serum, and host cell contact are each thought to convert the T3SS injectisome to a secretion-competent state through a poorly defined mechanism.
Formal Description
Interaction-ID: 24371

drug/chemical compound

Ca2+

affects_activity of

process

T3SS

Comment Type IV pili and T3SS gene expression are positively regulated by Vfr. The biological significance of this relationship reflects the adherence properties provided by type IV pili, which function as the primary adhesin for host-contact-dependent expression of the T3SS.
Formal Description
Interaction-ID: 24377

increases_activity of

process

T3SS