General Information:

Id: 2,586
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Diaz MR et al.(2011) Intrinsic and Extrinsic Regulation of Type III Secretion Gene Expression in Pseudomonas Aeruginosa. Front Microbiol 2: 89 [PMID: 21833328]

Interaction Information:

Comment The P. aeruginosa type III secretion system (T3SS) contributes to virulence in ameba, insect, zebrafish, and mammalian infection models and protects P. aeruginosa from phagocytosis irrespective of whether the phagocyte is an ameba or a human macrophage.
Formal Description
Interaction-ID: 24363

process

P. aeruginosa infection

increases_activity of

process

T3SS

in ameba, insect, zebrafish, and mammalian infection models
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24364

process

T3SS

increases_transport of

gene/protein

exoS

into the host cell
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24365

process

T3SS

increases_transport of

gene/protein

exoT

into the host cell
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24366

process

T3SS

increases_transport of

gene/protein

exoU

into the host cell
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24367

process

T3SS

increases_transport of

gene/protein

exoY

into the host cell
Comment P. aeruginosa uses the injectisome to translocate at least five effector proteins (ExoS, ExoT, ExoU, ExoY, and FliC) into host cells.
Formal Description
Interaction-ID: 24368

process

T3SS

increases_transport of

gene/protein

fliC

into the host cell
Comment The T3SS translocated effectors facilitate phagocytic avoidance, tissue invasion and systemic spread, and modulate the inflammatory response.
Formal Description
Interaction-ID: 24369

process

T3SS

decreases_activity of

process

phagocytosis

Comment Low Ca2+, serum, and host cell contact are each thought to convert the T3SS injectisome to a secretion-competent state through a poorly defined mechanism.
Formal Description
Interaction-ID: 24371

drug/chemical compound

Ca2+

affects_activity of

process

T3SS

Comment Although CF and non-CF patients are initially colonized with nearly identical strains of P. aeruginosa, the majority of chronic CF isolates are mucoid and lack T3SS gene expression.
Formal Description
Interaction-ID: 24372

process

P. aeruginosa infection, chronic

increases_quantity of

phenotype

mucoid strain

in patients witn CF
Comment Mucoid conversion results from overproduction of the alginate polysaccharide and is associated with a decline in lung function and clinical prognosis.
Formal Description
Interaction-ID: 24373

cellular component

(alginate)n

increases_quantity of

phenotype

mucoid strain

in patients witn CF
Comment Alginate biosynthesis is regulated by the AlgU alternative sigma factor and the membrane-bound MucA anti-sigma factor.
Formal Description
Interaction-ID: 24375

gene/protein

algU

increases_quantity of

cellular component

(alginate)n

Comment Alginate biosynthesis is regulated by the AlgU alternative sigma factor and the membrane-bound MucA anti-sigma factor.
Formal Description
Interaction-ID: 24376

gene/protein

mucA

decreases_quantity of

cellular component

(alginate)n

Comment Type IV pili and T3SS gene expression are positively regulated by Vfr. The biological significance of this relationship reflects the adherence properties provided by type IV pili, which function as the primary adhesin for host-contact-dependent expression of the T3SS.
Formal Description
Interaction-ID: 24377

increases_activity of

process

T3SS

Comment Besides ExsA only one additional transcriptional factor (PsrA) is known to directly regulate the T3SS.
Formal Description
Interaction-ID: 24378

gene/protein

exsA

increases_expression of

complex/PPI

T3SS complex

Comment Besides ExsA only one additional transcriptional factor (PsrA) is known to directly regulate the T3SS.
Formal Description
Interaction-ID: 24379

gene/protein

psrA

increases_expression of

complex/PPI

T3SS complex

Comment The DNA-binding activity of PsrA is directly inhibited by long chain fatty acids. Indeed T3SS gene expression is reduced in the presence of long chain fatty acids, although the biological significance of this observation is unclear.
Formal Description
Interaction-ID: 24380

drug/chemical compound

Long-chain fatty acid

decreases_activity of

gene/protein

psrA