General Information:

Id: 2,565 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Bernard CS et al.(2010) Nooks and crannies in type VI secretion regulation. J. Bacteriol. 192: 3850-3860 [PMID: 20511495]

Interaction Information:

Comment In P. aeruginosa, a pair of sensor kinases, RetS and LadS, regulates the expression of the HSI-1 T6SS gene cluster. T3SS and T6SS are inversely regulated. RetS is an activator of the expression of T3SS genes but represses genes involved in biofilm formation and T6SS expression. LadS has reciprocal effects.
Formal Description
Interaction-ID: 24053

gene/protein

retS

decreases_activity of

Comment In P. aeruginosa, a pair of sensor kinases, RetS and LadS, regulates the expression of the HSI-1 T6SS gene cluster. T3SS and T6SS are inversely regulated. RetS is an activator of the expression of T3SS genes but represses genes involved in biofilm formation and T6SS expression. LadS has reciprocal effects.
Formal Description
Interaction-ID: 24057

gene/protein

ladS

increases_activity of

Comment P. aeruginosa HSI-1 and HSI-3 loci are induced at different times during biofilm development: the expression of HSI-1 increases progressively during biofilm formation (from attachment to maturation), whereas HSI-3 is temporarily induced during the initial steps of biofilm development.
Formal Description
Interaction-ID: 24076

increases_expression of

complex/PPI

T6SS-HSI-1 complex

progressively during biofilm formation from attachment to maturation
Comment P. aeruginosa HSI-1 and HSI-3 loci are induced at different times during biofilm development: the expression of HSI-1 increases progressively during biofilm formation (from attachment to maturation), whereas HSI-3 is temporarily induced during the initial steps of biofilm development.
Formal Description
Interaction-ID: 24078

increases_expression of

complex/PPI

T6SS-HSI-3 complex

during the initial steps of biofilm development