General Information:

Id: 2,565
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
review
Reference: Bernard CS et al.(2010) Nooks and crannies in type VI secretion regulation. J. Bacteriol. 192: 3850-3860 [PMID: 20511495]

Interaction Information:

Comment In P. aeruginosa, a pair of sensor kinases, RetS and LadS, regulates the expression of the HSI-1 T6SS gene cluster. T3SS and T6SS are inversely regulated. RetS is an activator of the expression of T3SS genes but represses genes involved in biofilm formation and T6SS expression. LadS has reciprocal effects. This regulation mechanism suggests that the HSI-1 T6SS favors the chronic phase of infection.
Formal Description
Interaction-ID: 24052

gene/protein

retS

increases_expression of

complex/PPI

T3SS complex

Comment In P. aeruginosa, a pair of sensor kinases, RetS and LadS, regulates the expression of the HSI-1 T6SS gene cluster. T3SS and T6SS are inversely regulated. RetS is an activator of the expression of T3SS genes but represses genes involved in biofilm formation and T6SS expression. LadS has reciprocal effects.
Formal Description
Interaction-ID: 24053

gene/protein

retS

decreases_activity of

Comment In P. aeruginosa, a pair of sensor kinases, RetS and LadS, regulates the expression of the HSI-1 T6SS gene cluster. T3SS and T6SS are inversely regulated. RetS is an activator of the expression of T3SS genes but represses genes involved in biofilm formation and T6SS expression. LadS has reciprocal effects.
Formal Description
Interaction-ID: 24054

gene/protein

retS

decreases_expression of

complex/PPI

T6SS-HSI-1 complex

Comment In P. aeruginosa, a pair of sensor kinases, RetS and LadS, regulates the expression of the HSI-1 T6SS gene cluster. T3SS and T6SS are inversely regulated. RetS is an activator of the expression of T3SS genes but represses genes involved in biofilm formation and T6SS expression. LadS has reciprocal effects.
Formal Description
Interaction-ID: 24055

gene/protein

ladS

increases_expression of

complex/PPI

T6SS-HSI-1 complex

Comment In P. aeruginosa, a pair of sensor kinases, RetS and LadS, regulates the expression of the HSI-1 T6SS gene cluster. T3SS and T6SS are inversely regulated. RetS is an activator of the expression of T3SS genes but represses genes involved in biofilm formation and T6SS expression. LadS has reciprocal effects.
Formal Description
Interaction-ID: 24056

gene/protein

ladS

decreases_expression of

complex/PPI

T3SS complex

Comment In P. aeruginosa, a pair of sensor kinases, RetS and LadS, regulates the expression of the HSI-1 T6SS gene cluster. T3SS and T6SS are inversely regulated. RetS is an activator of the expression of T3SS genes but represses genes involved in biofilm formation and T6SS expression. LadS has reciprocal effects.
Formal Description
Interaction-ID: 24057

gene/protein

ladS

increases_activity of

Comment P. aeruginosa HSI-1 and HSI-3 loci are induced at different times during biofilm development: the expression of HSI-1 increases progressively during biofilm formation (from attachment to maturation), whereas HSI-3 is temporarily induced during the initial steps of biofilm development.
Formal Description
Interaction-ID: 24076

increases_expression of

complex/PPI

T6SS-HSI-1 complex

progressively during biofilm formation from attachment to maturation
Comment P. aeruginosa HSI-1 and HSI-3 loci are induced at different times during biofilm development: the expression of HSI-1 increases progressively during biofilm formation (from attachment to maturation), whereas HSI-3 is temporarily induced during the initial steps of biofilm development.
Formal Description
Interaction-ID: 24078

increases_expression of

complex/PPI

T6SS-HSI-3 complex

during the initial steps of biofilm development
Comment In P. aeruginosa, the nucleoid-associated H-NS-like protein MvaT represses the HSI-2 and HSI-3 T6SS gene clusters.
Formal Description
Interaction-ID: 24079

gene/protein

mvaT

decreases_expression of

complex/PPI

T6SS-HSI-2 complex

DNA microarray approach
Comment In P. aeruginosa, the nucleoid-associated H-NS-like protein MvaT represses the HSI-2 and HSI-3 T6SS gene clusters.
Formal Description
Interaction-ID: 24084

gene/protein

mvaT

decreases_expression of

complex/PPI

T6SS-HSI-3 complex

DNA microarray approach
Comment The P. aeruginosa MvfR transcription factor indirectly induces the expression of the HSI-2 and HSI-3 loci and represses the expression of the HSI-1 locus through the control of the production of the hydroxyalkylquinoline (HAQ) QS molecule.
Formal Description
Interaction-ID: 24104

gene/protein

mvfR

increases_expression of

complex/PPI

T6SS-HSI-2 complex

DNA microarray, RT-PCR appoach
Comment The P. aeruginosa MvfR transcription factor indirectly induces the expression of the HSI-2 and HSI-3 loci and represses the expression of the HSI-1 locus through the control of the production of the hydroxyalkylquinoline (HAQ) QS molecule.
Formal Description
Interaction-ID: 24106

gene/protein

mvfR

increases_expression of

complex/PPI

T6SS-HSI-3 complex

DNA microarray, RT-PCR appoach
Comment The P. aeruginosa MvfR transcription factor indirectly induces the expression of the HSI-2 and HSI-3 loci and represses the expression of the HSI-1 locus through the control of the production of the hydroxyalkylquinoline (HAQ) QS molecule.
Formal Description
Interaction-ID: 24107

gene/protein

mvfR

decreases_expression of

complex/PPI

T6SS-HSI-1 complex

DNA microarray, RT-PCR appoach
Comment The P. aeruginosa MvfR transcription factor indirectly induces the expression of the HSI-2 and HSI-3 loci and represses the expression of the HSI-1 locus through the control of the production of the hydroxyalkylquinoline (HAQ) QS molecule.
Formal Description
Interaction-ID: 24116

gene/protein

mvfR

affects_quantity of

drug/chemical compound

2-Heptyl-4-quinolone, HHQ

4-hydroxy-2-alkylquinoline, HAQs include HHQ
Comment The P. aeruginosa HSI-2 locus is regulated by PsrA, a TetR-like transcription factor which controls fatty acid metabolism and O-antigen biosynthesis.
Formal Description
Interaction-ID: 24119

gene/protein

psrA

affects_expression of

complex/PPI

T6SS-HSI-2 complex

DNA microarray approach
Comment RsmZ and rsmY titrate and sequester the RNA binding protein RsmA, a protein which acts as a translational repressor of target genes. RsmA is a translational repressor of the HSI-1 mRNAs whereas GacSA and rsm function as activators of the HSI-1 locus.
Formal Description
Interaction-ID: 28406

gene/protein

rsmA

decreases_expression of

complex/PPI

T6SS-HSI-1 complex

DNA microarray approach
Comment The P. aeruginosa MvfR transcription factor indirectly induces the expression of the HSI-2 and HSI-3 loci and represses the expression of the HSI-1 locus through the control of the production of the hydroxyalkylquinoline (HAQ) QS molecule.
Formal Description
Interaction-ID: 28450

gene/protein

mvfR

affects_quantity of

drug/chemical compound

2-Heptyl-3-hydroxy-4-quinolone, PQS

4-hydroxy-2-alkylquinoline, HAQs include PQS