General Information:

Id: 2,545 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Primary cultured conjunctival epithelial cells or human conjunctiva epithelial cell line Chang, infected with P. aeruginosa
article
Reference: Venza I et al.(2009) Pseudomonas aeruginosa induces interleukin-8 (IL-8) gene expression in human conjunctiva through the recruitment of both RelA and CCAAT/enhancer-binding protein beta to the IL-8 promoter. J. Biol. Chem. 284: 4191-4199 [PMID: 19064995]

Interaction Information:

Comment P. aeruginosa-induced IL-8 promoter activation in human conjunctival epithelial cells occurs through 1) the integrity of both the binding sites for C/EBPbeta and NF-kappaB, 2) the formation of a ternary complex of C/EBPbeta and the RelA subunit of NF-kappaB within IL-8 promoter, and 3) the independent binding of C/EBPbeta and RelA to their respective consensus sites. The enhancement of the IL-8 production by P. aeruginosa has a functional relevance in that it accounts for the activation of an innate immune response by the conjunctival epithelium following the sensing of the whole bacterium presence.
Formal Description
Interaction-ID: 23785

gene/protein

CXCL8

increases_activity of

process

immune response