General Information:

Id: 2,545 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Primary cultured conjunctival epithelial cells or human conjunctiva epithelial cell line Chang, infected with P. aeruginosa
Reference: Venza I et al.(2009) Pseudomonas aeruginosa induces interleukin-8 (IL-8) gene expression in human conjunctiva through the recruitment of both RelA and CCAAT/enhancer-binding protein beta to the IL-8 promoter. J. Biol. Chem. 284: 4191-4199 [PMID: 19064995]

Interaction Information:

Comment P. aeruginosa activation of p38MAPK resulted in the (i) up-regulation of IL-8 at the transcriptional level and (ii) phosphorylation and binding to IL-8 promoter of the transcription factor C/EBPbeta. The activation of C/EBPbeta responsible for IL-8 expression was p38MAPK-dependent because the inhibitor of this kinase completely abolished phosphorylation and DNA binding of C/EBPbeta This result is in agreement with literature data showing that p38MAPK can directly phosphorylate subunits of C/EBP transcription factors, in particular C/EBPbeta.
Formal Description
Interaction-ID: 23700


p38 MAPK

increases_expression of