General Information:

Id: 2,519 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
TLR5-transfected HEK cells or human neutrophils , incubated with with recombinant AprA of P. aeruginosa strain PAO1
article
Reference: Bardoel BW et al.(2011) Pseudomonas evades immune recognition of flagellin in both mammals and plants. PLoS Pathog. 7 [PMID: 21901099]

Interaction Information:

Comment Stimulation of HEK/TLR5 with flagellin triggers the activation of NF-kappaB and the secretion of Interleukin 8 (IL-8). AprA prevents flagellin-induced IL-8 production by HEK/TLR5 cells.
Formal Description
Interaction-ID: 23453

gene/protein

aprA

decreases_quantity of

gene/protein

CXCL8